murine ykl 40 Search Results


bovine cii  (Chondrex Inc)
93
Chondrex Inc bovine cii
Cl-amidine treatment reduces clinical disease activity and joint destruction in CIA. Arthritis was induced by two injections of <t>bovine</t> <t>CII</t> in CFA at days 0 and 21. Mice were treated as described in Materials and Methods and assessed three times weekly for clinical disease activity. A, All treatment groups showed significantly reduced clinical disease activity scores compared with the PBS vehicle control beginning on day 27 and continuing through day 35. *p < 0.05 at day 24 and p < 0.03 at day 27 for 10-mg group, #p < 0.01 for 50-mg group, ***p < 0.03 for 10- and 50-mg groups, and p < 0.05 for 1-mg group. (n = 8 for all groups, except n = 7 for 1-mg group.) B, Histologic sections were scored for changes in synovial inflammation, pannus, cartilage damage, and bone damage, all on a scale of 0–5. C, Sections were scored for C3 deposition in the synovium and cartilage. Data are expressed as the mean ± SEM based upon a set of five joints per animal. Treatment with Cl-amidine resulted in decreased histopathology scores for all parameters in the 10- and 50-mg/kg/d treatment groups compared with the PBS vehicle group. (n = 8 for all groups, except n = 7 for 1-mg group.) *p ≤ 0.03, **p < 0.02, ***p < 0.01.
Bovine Cii, supplied by Chondrex Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/murine+ykl+40/ELISA+Grade+Bovine+Type+II+Collagen/pmc03085980-146-25-27
Average 93 stars, based on 1 article reviews
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murine ykl 40  (Boster Bio)
93
Boster Bio murine ykl 40
Cl-amidine treatment reduces clinical disease activity and joint destruction in CIA. Arthritis was induced by two injections of <t>bovine</t> <t>CII</t> in CFA at days 0 and 21. Mice were treated as described in Materials and Methods and assessed three times weekly for clinical disease activity. A, All treatment groups showed significantly reduced clinical disease activity scores compared with the PBS vehicle control beginning on day 27 and continuing through day 35. *p < 0.05 at day 24 and p < 0.03 at day 27 for 10-mg group, #p < 0.01 for 50-mg group, ***p < 0.03 for 10- and 50-mg groups, and p < 0.05 for 1-mg group. (n = 8 for all groups, except n = 7 for 1-mg group.) B, Histologic sections were scored for changes in synovial inflammation, pannus, cartilage damage, and bone damage, all on a scale of 0–5. C, Sections were scored for C3 deposition in the synovium and cartilage. Data are expressed as the mean ± SEM based upon a set of five joints per animal. Treatment with Cl-amidine resulted in decreased histopathology scores for all parameters in the 10- and 50-mg/kg/d treatment groups compared with the PBS vehicle group. (n = 8 for all groups, except n = 7 for 1-mg group.) *p ≤ 0.03, **p < 0.02, ***p < 0.01.
Murine Ykl 40, supplied by Boster Bio, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/murine+ykl+40/Human+recombinant+CHI3L1+(Chitinase-3-like+protein+1)+protein%2C+AF/pmc05681777-130-2-18
Average 93 stars, based on 1 article reviews
murine ykl 40 - by Bioz Stars, 2026-09
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murine ova specific ige  (Chondrex Inc)
93
Chondrex Inc murine ova specific ige
Cl-amidine treatment reduces clinical disease activity and joint destruction in CIA. Arthritis was induced by two injections of <t>bovine</t> <t>CII</t> in CFA at days 0 and 21. Mice were treated as described in Materials and Methods and assessed three times weekly for clinical disease activity. A, All treatment groups showed significantly reduced clinical disease activity scores compared with the PBS vehicle control beginning on day 27 and continuing through day 35. *p < 0.05 at day 24 and p < 0.03 at day 27 for 10-mg group, #p < 0.01 for 50-mg group, ***p < 0.03 for 10- and 50-mg groups, and p < 0.05 for 1-mg group. (n = 8 for all groups, except n = 7 for 1-mg group.) B, Histologic sections were scored for changes in synovial inflammation, pannus, cartilage damage, and bone damage, all on a scale of 0–5. C, Sections were scored for C3 deposition in the synovium and cartilage. Data are expressed as the mean ± SEM based upon a set of five joints per animal. Treatment with Cl-amidine resulted in decreased histopathology scores for all parameters in the 10- and 50-mg/kg/d treatment groups compared with the PBS vehicle group. (n = 8 for all groups, except n = 7 for 1-mg group.) *p ≤ 0.03, **p < 0.02, ***p < 0.01.
Murine Ova Specific Ige, supplied by Chondrex Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
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hrp conjugated goat anti murine igg  (Jackson Immuno)
98
Jackson Immuno hrp conjugated goat anti murine igg
Cl-amidine treatment reduces clinical disease activity and joint destruction in CIA. Arthritis was induced by two injections of <t>bovine</t> <t>CII</t> in CFA at days 0 and 21. Mice were treated as described in Materials and Methods and assessed three times weekly for clinical disease activity. A, All treatment groups showed significantly reduced clinical disease activity scores compared with the PBS vehicle control beginning on day 27 and continuing through day 35. *p < 0.05 at day 24 and p < 0.03 at day 27 for 10-mg group, #p < 0.01 for 50-mg group, ***p < 0.03 for 10- and 50-mg groups, and p < 0.05 for 1-mg group. (n = 8 for all groups, except n = 7 for 1-mg group.) B, Histologic sections were scored for changes in synovial inflammation, pannus, cartilage damage, and bone damage, all on a scale of 0–5. C, Sections were scored for C3 deposition in the synovium and cartilage. Data are expressed as the mean ± SEM based upon a set of five joints per animal. Treatment with Cl-amidine resulted in decreased histopathology scores for all parameters in the 10- and 50-mg/kg/d treatment groups compared with the PBS vehicle group. (n = 8 for all groups, except n = 7 for 1-mg group.) *p ≤ 0.03, **p < 0.02, ***p < 0.01.
Hrp Conjugated Goat Anti Murine Igg, supplied by Jackson Immuno, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 98 stars, based on 1 article reviews
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Cl-amidine treatment reduces clinical disease activity and joint destruction in CIA. Arthritis was induced by two injections of bovine CII in CFA at days 0 and 21. Mice were treated as described in Materials and Methods and assessed three times weekly for clinical disease activity. A, All treatment groups showed significantly reduced clinical disease activity scores compared with the PBS vehicle control beginning on day 27 and continuing through day 35. *p < 0.05 at day 24 and p < 0.03 at day 27 for 10-mg group, #p < 0.01 for 50-mg group, ***p < 0.03 for 10- and 50-mg groups, and p < 0.05 for 1-mg group. (n = 8 for all groups, except n = 7 for 1-mg group.) B, Histologic sections were scored for changes in synovial inflammation, pannus, cartilage damage, and bone damage, all on a scale of 0–5. C, Sections were scored for C3 deposition in the synovium and cartilage. Data are expressed as the mean ± SEM based upon a set of five joints per animal. Treatment with Cl-amidine resulted in decreased histopathology scores for all parameters in the 10- and 50-mg/kg/d treatment groups compared with the PBS vehicle group. (n = 8 for all groups, except n = 7 for 1-mg group.) *p ≤ 0.03, **p < 0.02, ***p < 0.01.

Journal: Journal of immunology (Baltimore, Md. : 1950)

Article Title: N-?-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-L-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis

doi: 10.4049/jimmunol.1001620

Figure Lengend Snippet: Cl-amidine treatment reduces clinical disease activity and joint destruction in CIA. Arthritis was induced by two injections of bovine CII in CFA at days 0 and 21. Mice were treated as described in Materials and Methods and assessed three times weekly for clinical disease activity. A, All treatment groups showed significantly reduced clinical disease activity scores compared with the PBS vehicle control beginning on day 27 and continuing through day 35. *p < 0.05 at day 24 and p < 0.03 at day 27 for 10-mg group, #p < 0.01 for 50-mg group, ***p < 0.03 for 10- and 50-mg groups, and p < 0.05 for 1-mg group. (n = 8 for all groups, except n = 7 for 1-mg group.) B, Histologic sections were scored for changes in synovial inflammation, pannus, cartilage damage, and bone damage, all on a scale of 0–5. C, Sections were scored for C3 deposition in the synovium and cartilage. Data are expressed as the mean ± SEM based upon a set of five joints per animal. Treatment with Cl-amidine resulted in decreased histopathology scores for all parameters in the 10- and 50-mg/kg/d treatment groups compared with the PBS vehicle group. (n = 8 for all groups, except n = 7 for 1-mg group.) *p ≤ 0.03, **p < 0.02, ***p < 0.01.

Article Snippet: IgG2a and IgG1 Abs to murine and bovine CII were measured in triplicate by specific ELISA by coating 96-well plates with 5 μg/ml murine or bovine CII (Chondrex).

Techniques: Activity Assay, Histopathology

Cl-amidine treatment reduces serum and synovial citrulline content in vivo. A, Synovial citrulline content. Arthritis was induced in control and Cl-amidine–treated mice by a single injection of bovine CII in CFA at day 0. Mice were treated daily, beginning on day 0, for 21 d with Cl-amidine (1, 10, or 50 mg/kg) in PBS or PBS alone or were left untreated. Results are displayed by dose (left panel) and grouped (right panel) as unimmunized (WT), control (PBS and untreated), and Cl-amidine (1, 10, or 50 mg/kg)-treated mice. B, Serum citrulline content was measured in mice at day 35. Results are displayed by dose (left panel) and grouped (right panel) as control (untreated and PBS) and Cl-amidine (1, 10, or 50 mg/kg)-treated mice.

Journal: Journal of immunology (Baltimore, Md. : 1950)

Article Title: N-?-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-L-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis

doi: 10.4049/jimmunol.1001620

Figure Lengend Snippet: Cl-amidine treatment reduces serum and synovial citrulline content in vivo. A, Synovial citrulline content. Arthritis was induced in control and Cl-amidine–treated mice by a single injection of bovine CII in CFA at day 0. Mice were treated daily, beginning on day 0, for 21 d with Cl-amidine (1, 10, or 50 mg/kg) in PBS or PBS alone or were left untreated. Results are displayed by dose (left panel) and grouped (right panel) as unimmunized (WT), control (PBS and untreated), and Cl-amidine (1, 10, or 50 mg/kg)-treated mice. B, Serum citrulline content was measured in mice at day 35. Results are displayed by dose (left panel) and grouped (right panel) as control (untreated and PBS) and Cl-amidine (1, 10, or 50 mg/kg)-treated mice.

Article Snippet: IgG2a and IgG1 Abs to murine and bovine CII were measured in triplicate by specific ELISA by coating 96-well plates with 5 μg/ml murine or bovine CII (Chondrex).

Techniques: In Vivo, Injection

Cl-amidine treatment reduces IgG autoantibody response to mouse but not bovine CII. Sera from individual mice were incubated on a 96-well plate coated with bovine (A) or mouse (B) CII. The presence of anti-mouse IgG1 or IgG2a Ab was detected by ELISA. The 50-mg/kg/d group showed significantly lower IgG1 anti-mouse CII Ab titers, whereas the 10-mg/kg/d group had significantly lower IgG2a anti-mouse CII Ab titers compared with the PBS vehicle control group at day 35. C, IgG1 and IgG2a Ab titers at day 35. *p ≤ 0.05. (n = 8 for all group, except n = 7 for 1-mg group.)

Journal: Journal of immunology (Baltimore, Md. : 1950)

Article Title: N-?-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-L-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis

doi: 10.4049/jimmunol.1001620

Figure Lengend Snippet: Cl-amidine treatment reduces IgG autoantibody response to mouse but not bovine CII. Sera from individual mice were incubated on a 96-well plate coated with bovine (A) or mouse (B) CII. The presence of anti-mouse IgG1 or IgG2a Ab was detected by ELISA. The 50-mg/kg/d group showed significantly lower IgG1 anti-mouse CII Ab titers, whereas the 10-mg/kg/d group had significantly lower IgG2a anti-mouse CII Ab titers compared with the PBS vehicle control group at day 35. C, IgG1 and IgG2a Ab titers at day 35. *p ≤ 0.05. (n = 8 for all group, except n = 7 for 1-mg group.)

Article Snippet: IgG2a and IgG1 Abs to murine and bovine CII were measured in triplicate by specific ELISA by coating 96-well plates with 5 μg/ml murine or bovine CII (Chondrex).

Techniques: Incubation, Enzyme-linked Immunosorbent Assay